One nuance that often gets lost in coverage of this transition: natural does not mean universally safe for everyone.
Kantha Shelke, a food scientist at Johns Hopkins University, told ABC News in June 2026 that two natural dyes deserve particular attention from sensitive consumers.
Carmine, also called cochineal extract or E120, is derived from crushed female cochineal insects and is widely used as a red dye in yogurts, candies, juices, and some processed meats. Our deep-dive on carmine covers all the product categories and label names where it appears. It can trigger allergic reactions ranging from hives to, in rare cases, anaphylaxis. People with shellfish allergies are sometimes (but not always) reactive to carmine. The FDA has required carmine and cochineal extract to be declared by name on food labels since 2011, specifically because of its allergy potential. Crucially, carmine is not vegan or vegetarian.
Annatto, a yellow-orange dye from the seeds of the Bixa orellana tree, is commonly used in cheeses, snack foods, and butter. It has been associated with cases of chronic urticaria (hives) in sensitive individuals, and some research suggests it may trigger reactions in people with aspirin sensitivity or salicylate intolerance.
Most other natural color alternatives, including beet juice, turmeric, spirulina, saffron, and grape skin extract, are considered low-risk for most people.
The transition away from petroleum-based dyes is a meaningful improvement for public health. But the new ingredient list still warrants reading, particularly for people with food allergies or specific sensitivities.