PFAS stands for per- and polyfluoroalkyl substances. The group covers thousands of synthetic chemicals that share one defining property: they contain chains of carbon-fluorine bonds. Carbon-fluorine bonds are among the strongest in organic chemistry. This strength is what makes PFAS so useful industrially. It is also why they do not break down.
In the environment, PFAS persist indefinitely, accumulating in soil, groundwater, and the bodies of animals and humans. They earned the name "forever chemicals" because no natural process degrades them on any human-relevant timescale.
In food packaging specifically, PFAS were historically prized for their ability to resist grease, oil, and moisture. A pizza box that does not absorb oil through the cardboard, a microwave popcorn bag with a heat-resistant inner lining, a fast food wrapper that keeps french fries from soaking through the paper: all of these functions have traditionally relied on PFAS coatings or treatments.
The Health Concern
Decades of research have established that PFAS exposure is not benign. The European Food Safety Authority (EFSA) completed a comprehensive assessment of dietary PFAS exposure in 2020, setting a tolerable weekly intake for the four most studied compounds (PFOS, PFOA, PFNA, and PFHxS) combined at 4.4 nanograms per kilogram of body weight. EFSA concluded that a significant proportion of the European population was already exceeding this threshold through food, water, and environmental exposure.
Food-contact packaging is one of the routes through which PFAS migrate into food. PFAS in packaging coatings can transfer into food during contact, particularly when the food is hot, fatty, or acidic. A 2021 study that tested food packaging from fast food chains and supermarkets across Europe found PFAS in the vast majority of samples.
The documented health effects associated with long-term PFAS exposure include:
- Thyroid disruption: PFAS interfere with thyroid hormone function, affecting metabolism, development, and cardiovascular health
- Immune system suppression: studies have found associations between PFAS exposure and reduced vaccine response in children, suggesting broader immune function impacts
- Liver effects: elevated liver enzymes and non-alcoholic liver disease have been associated with PFAS exposure in epidemiological studies
- Developmental effects: prenatal and early-life exposure has been linked to lower birth weight and altered developmental trajectories
- Cancer: PFOA and PFOS, two of the most extensively studied PFAS compounds, have been classified as possibly or probably carcinogenic to humans by the International Agency for Research on Cancer
None of these effects result from a single exposure. The concern is chronic, low-level accumulation over years and decades, combined with the fact that PFAS do not leave the body readily once ingested.